LMNA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LMNA.
Immunogen
A synthetic peptide corresponding to amino acids 249-266 of human Lamin A/C.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of human LMNA in 15 ugs of HeLa cell lysate. Using LMNA polyclonal antibody (Cat # PAB0340) at 1 : 1000 dilution. -
Gene Info — LMNA
Entrez GeneID
4000Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress.
Nakamura M, Yamada M, Ohsawa T, Morisawa H, Nishine T, Nishimura O, Toda T.
Biochimica et Biophysica Acta 2006 Jul; 1763(9):977.
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S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors.
Lei JX, Liu QY, Sodja C, LeBlanc J, Ribecco-Lutkiewicz M, Smith B, Charlebois C, Walker PR, Sikorska M.
Cell Death and Differentiation 2005 May; 12(11):1368.
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DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways.
Siripurapu V, Meth J, Kobayashi N, Hamaguchi M.
Journal of Molecular Biology 2004 Dec; 346(1):83.
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Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress.
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