Formalin-fixed paraffin-embedded tissue sections of human heart with cardiomyopathy stained for BAK1 expression. Using BAK1 polyclonal antibody (Cat # PAB0333) at 1 : 2000 (A and B) . Hematoxylin-eosin counterstain.
Formalin-fixed paraffin-embedded human tissue for Bak expression using BAK1 polyclonal antibody (Cat # PAB0333) at 1 : 2000. A. Ductal breast carcinoma. B. Lymphocyte infiltration in soft tissue adjacent to colon carcinoma. Hematoxylin-eosin counterstain.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq
BCL2-like 7 protein,Bcl-2 homologous antagonist/killer,OTTHUMP00000016211,OTTHUMP00000039620,apoptosis regulator BAK,pro-apoptotic protein BAK