Formalin-fixed, paraffin-embedded human tissues stained for BAG5 expression. Using BAG5 polyclonal antibody (Cat # PAB0332) at 1 : 2000. A. normal placenta. B. breast cancer. C. normal spleen. normal cervix epithelium. Hematoxylin-eosin counterstain.
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq