Formalin-fixed paraffin-embedded tissue section of human reactive tonsil stained for MAP3K5 expression. Using MAP3K5 polyclonal antibody (Cat # PAB0327) at 1 : 2000. A and A1. Low and high magnification, respectively. MAP3K5 expression was seen in the vasculature (endothelial cells). Hematoxylin-eosin counterstain.
Formalin-fixed paraffin-embedded tissue section of human small venous vessels stained for MAP3K5 expression. Using MAP3K5 polyclonal antibody (Cat # PAB0327) at 1 : 2000. MAP3K5 positive epithelial cells were seen. Hematoxylin-eosin counterstain.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq
MAP/ERK kinase kinase 5,MAPK/ERK kinase kinase 5,OTTHUMP00000017275,apoptosis signal regulating kinase