Formalin-fixed, paraffin-embedded human brain tissue tissue sections stained for APAF1 espression. Using APAF1 polyclonal antibody (Cat # PAB0325) at 1 : 2000. A. Brain stem. B. Cortex. Hematoxylin-eosin counterstain.
Formalin-fixed, paraffin-embedded tissue core of human glioma (grade II) stained for APAF1 espression. Using APAF1 polyclonal antibody (Cat # PAB0325) at 1 : 2000. A and A1. Low and high magnification, respectively Hematoxylin-eosin counterstain.
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq