Ticam1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Ticam1.
Immunogen
A synthetic peptide corresponding to amino acids 143-158 of mouse Ticam1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% gelatin, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of Ticam1 in mouse spleen lysate. Using Ticam1 polyclonal antibody (Cat # PAB0317) at 1 : 1000 dilution. -
Gene Info — TICAM1
Entrez GeneID
148022Gene Name
TICAM1
Gene Alias
MGC35334, PRVTIRB, TICAM-1, TRIF
Gene Description
toll-like receptor adaptor molecule 1
Omim ID
607601Gene Ontology
HyperlinkGene Summary
TRIF, or TICAM1, is a Toll/IL1R (MIM 147810) (TIR) domain-containing adaptor molecule, like MYD88 (MIM 602170) and TIRAP (MIM 606252), that induces interferon-beta (IFNB; MIM 147640), specifically interacts with TLR3 (MIM 603029), and activates nuclear factor kappa-B (NFKB; see MIM 164011).[supplied by OMIM
Other Designations
TIR domain containing adaptor inducing interferon-beta|TIR domain-containing adaptor molecule 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-{beta} Production.
Gabhann JN, Higgs R, Brennan K, Thomas W, Damen JE, Ben Larbi N, Krystal G, Jefferies CA.
Journal of Immunology 2010 Mar; 184(5):2314.
Application:WB, Mouse, Mouse bone marrow-derived macrophages.
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Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways.
Chassin C, Goujon JM, Darche S, du Merle L, Bens M, Cluzeaud F, Werts C, Ogier-Denis E, Le Bouguenec C, Buzoni-Gatel D, Vandewalle A.
Journal of Immunology 2006 Oct; 177(7):4773.
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Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.
Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M.
The Journal of Biological Chemistry 2004 Dec; 280(7):5491.
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Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-{beta} Production.
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