Formalin-fixed, paraffin-embedded tissue human colon microarray stained for CARD8 expression at 1 : 2000. Using CARD8 polyclonal antibody (Cat # PAB0281) . A-A2, sucessively higher magnifications of the microarray. A, low magnification overview. A1, differential CARD8 staining between tissue cores is observed. A2, Areas of intense CARD8 staining in a colon carcinoma tissue core. Hematoxylin eosin counterstain.
Formalin-fixed, paraffin-embedded tumor/normal adjacent tissue cores from a human colon tissue microarray stained for CARD8 expression at 1:2000 using CARD8 polyclonal antibody (Cat # PAB0281). A and B are tumor tissue cores. A1 and B1 are the matched normal adjacent cores from A and B, respectively. Hematoxylin-eosin counterstain.
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
CARD inhibitor of NF-kappaB-activating ligands,CARD8 isoform T47,CARD8 isoform T51,CARD8 isoform T60,apoptotic protein NDPP1,tumor up-regulated CARD-containing antagonist of caspase nine