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Last updated: 2016/12/4
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CARD8 polyclonal antibody

  • Catalog # : PAB0281
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against full length recombinant CARD8.
  • Immunogen:
  • Recombinant protein corresponding to full length human CARD8.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In serum (0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of CARD8 in tumor cell lines. Using CARD8 polyclonal antibody (Cat # PAB0281) at 1 : 2000. Cell lysates were normalized for total protein content.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed, paraffin-embedded tissue human colon microarray stained for CARD8 expression at 1 : 2000. Using CARD8 polyclonal antibody (Cat # PAB0281) . A-A2, sucessively higher magnifications of the microarray. A, low magnification overview. A1, differential CARD8 staining between tissue cores is observed. A2, Areas of intense CARD8 staining in a colon carcinoma tissue core. Hematoxylin eosin counterstain.
  • Immunohistochemistry
  • Immunohistochemistry
  • Formalin-fixed, paraffin-embedded tumor/normal adjacent tissue cores from a human colon tissue microarray stained for CARD8 expression at 1:2000 using CARD8 polyclonal antibody (Cat # PAB0281).
    A and B are tumor tissue cores.
    A1 and B1 are the matched normal adjacent cores from A and B, respectively.
    Hematoxylin-eosin counterstain.
  • Immunoprecipitation
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • CARD8
  • Gene Alias:
  • CARDINAL,DACAR,DKFZp779L0366,Dakar,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP,NDPP1,TUCAN
  • Gene Description:
  • caspase recruitment domain family, member 8
  • Gene Summary:
  • The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
  • Other Designations:
  • CARD inhibitor of NF-kappaB-activating ligands,CARD8 isoform T47,CARD8 isoform T51,CARD8 isoform T60,apoptotic protein NDPP1,tumor up-regulated CARD-containing antagonist of caspase nine
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