TRAF1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRAF1.
Immunogen
A synthetic peptide corresponding to amino acids 1-22 of human TRAF1.
Sequence
MASSSGSSPRPAPDENEFPFG
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TRAF1 in normal human tissues. Using TRAF1 polyclonal antibody (Cat # PAB0274) at 1 : 2000. TRAF1 is observed at 50-50 KDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF1 degradation fragments.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded human lymphoma tissue section stained for TRAF1 expression. Using TRAF1 polyclonal antibody (Cat # PAB0274) at 1 : 2000. Hematoxylin-eosin counterstain. A1 is a higher magnification of A.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded human tissue sections stained for TRAF1 expression. Using TRAF1 polyclonal antibody (Cat # PAB0274) at 1 : 2000. Hematoxylin-eosin counterstain. A, A1 : Formalin-fixed, paraffin-embedded human lymphoma tissue section stained for TRAF1 expression. Using TRAF1 polyclonal antibody (Cat # PAB0274) at 1 : 2000. Hematoxylin-eosin counterstain. A, Hodgkin's Disease, the Reed-Sternberg cells are positive for TRAF1 expression. B, lymph node, dendritic-like cells are positive for TRAF1 expression. A1 and B1 are higher magnifications from A and B, respectively. .Immunoprecipitation
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Gene Info — TRAF1
Entrez GeneID
7185Gene Name
TRAF1
Gene Alias
EBI6, MGC:10353
Gene Description
TNF receptor-associated factor 1
Omim ID
601711Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. [provided by RefSeq
Other Designations
Epstein-Bar virus-induced protein 6|OTTHUMP00000022000
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Interactome
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Pathway
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Disease
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Publication Reference
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TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.
Zapata JM, Krajewska M, Krajewski S, Kitada S, Welsh K, Monks A, McCloskey N, Gordon J, Kipps TJ, Gascoyne RD, Shabaik A, Reed JC.
Journal of Immunology 2000 Nov; 165(9):5084.
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TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.
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