Western blot analysis of BIRC5. Using BIRC5 polyclonal antibody (Cat # PAB0272) at 1 : 2000. BIRC5 was detected in the two tumor cell lines, Jurkat (T cell lymphoma) and RS11846 (non-Hodgkin's lymphoma), but not in lysates from normal tissues. BIRC5 RP, full-length recombiant human BIRC5 protein was used as a positive control.
Immunohistochemical analysis of BIRC5 in formalin-fixed, paraffin-embedded human prostate and breast cancer. Using BIRC5 polyclonal antibody (Cat # PAB0272) at 1 : 2000. A and A1, prostate cancer at low and high magnification, respectively. B and B1, breast cancer. B1 is a high magnification of an area of metastasis. Hematoxylin-eosin counterstain.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
apoptosis inhibitor 4,baculoviral IAP repeat-containing protein 5,survivin variant 3 alpha