NLRP2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NLRP2 in differentiated THP-1 cells following IFN (interferon) g stimulation using NLRP2 polyclonal antibody (Cat # PAB0267) at 1 : 2000. TPA-differentiated THP-1 cells were cultured with 1000 units of IFNg for 0-24 hours as described in Bruey et al, 2004. Culturing differentiated THP-1 with IFNg resulted in transient elevations in NLRP2 expression which peaked at 4-8 h after INFg treatment.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NLRP2.
Immunogen
A synthetic peptide corresponding to amino acids 144-159 of human NLRP2.
Sequence
LGKEVFKGKKPDKDNR
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NLRP2 in differentiated THP-1 cells following IFN (interferon) g stimulation using NLRP2 polyclonal antibody (Cat # PAB0267) at 1 : 2000. TPA-differentiated THP-1 cells were cultured with 1000 units of IFNg for 0-24 hours as described in Bruey et al, 2004. Culturing differentiated THP-1 with IFNg resulted in transient elevations in NLRP2 expression which peaked at 4-8 h after INFg treatment.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — NLRP2
Entrez GeneID
55655Gene Name
NLRP2
Gene Alias
CLR19.9, FLJ20510, NALP2, NBS1, PAN1, PYPAF2
Gene Description
NLR family, pyrin domain containing 2
Omim ID
609364Gene Ontology
HyperlinkGene Summary
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
Other Designations
NACHT, LRR and PYD containing protein 2|NACHT, leucine rich repeat and PYD containing 2|PYRIN-Containing APAF1-like|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
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Interactome
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Disease
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