Products

Western Blot (Cell lysate)

Western blot analysis of NOD2. Using NOD2 polyclonal antibody (Cat # PAB0265) at 1 : 2000. 30 ug total protein was loaded per lane. Samples from human tumor cell lines : PPC-1 (prostate carcinoma) , NCI-H226 and NCI-H332M (lung carcinoma) , SF-268 (glioblastoma) , UO-31 and A498 (renal/kidney carcinoma) , SK-MEL-5 and SK-MEL-28 (melanoma) , and MCF-7 (breast carcinoma) . Lymphoma is from a cell line generated from a tumor growing in nude mice following injection of primary human lymphoma cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed, paraffin-embedded normal human colon stained for NOD2 expression. Using NOD2 polyclonal antibody (Cat # PAB0265) at 1 : 2000. A, tissue core from a colon tissue microarray. A1, high magnification of A. Hematoxylin-eosin counterstain.

Immunohistochemistry (Frozen sections)

Immunoprecipitation

Entrez GeneID

64127

Gene Name

NOD2

Gene Alias

ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1

Gene Description

nucleotide-binding oligomerization domain containing 2

Omim ID

181000 186580 266600 605956 607507

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq

Other Designations

NLR family, CARD domain containing 2|NOD-like receptor C2|OTTHUMP00000164224|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-bin