Western blot analysis of NLRP1 (NAC/CARD7) in adult human tissue lysates. Using NLRP1 polyclonal antibody (Cat # PAB0262) at 1 : 2000. Full-length NAC protein was detected at highest levels in kidney, brain and epidermis. A smaller band was detected in thymus, possibly representing a NLRP1 breakdown product or alternatively spliced form. 293T + NLRP1 : positive control, 293T cells transiently transfected with full-length NLRP1.
Formalin-fixed, paraffin-embedded normal human tissue sections stained for NLRP1 (CARD7/NAC) using NLRP1 polyclonal antibody (Cat # PAB0262) at 1 : 2000. A, epidermis. B, esophagus. C, uterine cervix. D, thymus. Hematoxylin-eosin counterstain. In A-C, NALP1 expression is associated with differentiation in stratified epithelial of the skin, esophagus, and cervix.
Formalin-fixed, paraffin-embedded human tissue sections stained for NLRP1 (NAC/CARD7) using using NLRP1 polyclonal antibody (Cat # PAB0262) at 1:2000. A, bone marrow. B, brain glioma core from a brain cancer microarray. A1 and B1 are higher magnifications of A and B, respectively. Hemaxotylin-eosin counterstain.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq
NACHT, LRR and PYD containing protein 1,NACHT, leucine rich repeat and PYD (pyrin domain) containing 1,NACHT, leucine rich repeat and PYD containing 1,caspase recruitment domain protein 7,death effector filament-forming Ced-4-like apoptosis protein,nucleo