Western blot analysis of BIRC2 in human prostate. Using BIRC2 polyclonal antibody (Cat # PAB0252) at 1 : 1000. PBH (benign prostate hyperplasia) , PIN (prostate intraepithelial neoplasia) . Elevated levels of BIRC2 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.
Immunohistochemical analysis of BIRC2 in formalin-fixed, paraffin-embedded human prostate. Using BIRC2 polyclonal antibody (Cat # PAB0252) at 1 : 2000. A, normal prostate. B, prostate intraepithelial neoplasia (PIN) . PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased BIRC2 expression is PIN and in prostate cancer compared to normal prostate.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. [provided by RefSeq
NFR2-TRAF signalling complex protein,apoptosis inhibitor 1,baculoviral IAP repeat-containing protein 2