CASP8 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded sections from a brain tumor tissue array stained for CASP8 expression using CASP8 polyclonal antibody (Cat # PAB0246) at 1 : 2000. A. Anaplastic glioma (Grade III, left) and Gemistocytoma (Grade II, right) cores showing negative and positive staining for CASP8, respectively. B. Higher magnification of the Gemistocytoma tumor (from A) .
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant CASP8.
Immunogen
Recombinant protein corresponding to full length active human CASP8.
Host
Rabbit
Reactivity
Gerbils, Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded sections from a brain tumor tissue array stained for CASP8 expression using CASP8 polyclonal antibody (Cat # PAB0246) at 1 : 2000. A. Anaplastic glioma (Grade III, left) and Gemistocytoma (Grade II, right) cores showing negative and positive staining for CASP8, respectively. B. Higher magnification of the Gemistocytoma tumor (from A) .Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — CASP8
Entrez GeneID
841Gene Name
CASP8
Gene Alias
ALPS2B, CAP4, FLICE, FLJ17672, MACH, MCH5, MGC78473
Gene Description
caspase 8, apoptosis-related cysteine peptidase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
Other Designations
FADD-homologous ICE/CED-3-like protease|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|Mch5 isoform alpha|OTTHUMP00000163718|OTTHUMP00000163719|OTTHUMP00000163720|caspase 8|caspase 8, apoptosis-related cysteine protease|cysteine protease|procaspase-8
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Interactome
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Pathway
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Disease
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Publication Reference
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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
Marchong MN, Yurkowski C, Ma C, Spencer C, Pajovic S, Gallie BL.
PLoS Genetics 2010 Apr; 6(4):e1000923.
Application：IHC-P, Mouse, Mouse eyes.
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Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S.
Experimental Neurology 2004 Oct; 189(2):261.
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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
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