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Last updated: 2016/12/4
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CASP3 polyclonal antibody

  • Catalog # : PAB0242
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against full length recombinant CASP3.
  • Immunogen:
  • Recombinant protein corresponding to full length human CASP3.
  • Host:
  • Rabbit
  • Reactivity:
  • Gerbils, Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In serum (0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of CASP3. Lysates from Jurkat cells (lane 1) , normal mammary tissue (lane 2) and surgical specimens from three invasive ductal carcinomas (lanes 3-5) were normalized for total protein content (50 ug/lane) and western blotted with CASP3 polyclonal antibody (Cat # PAB0242) . The ~32 kDa pro-CASP3 protein was detected in all samples. Active/cleaved CASP3 was identified in Jurkat (10 kDa small subunit, lane 1) and two ductal carcinomas (14-21 kDa large subunit) .
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of CASP3 expression in formalin-fixed, paraffin-embedded human reactive lymph node. Using CASP3 polyclonal antibody (Cat # PAB0242) at 1 : 2000. Staining is seen in the apoptosis-prone germinal center B lymphocytes of follicles. In constrast little or no staining is seen in the surrounding long-live mantle zone lymphocytes.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of CASP3 expression in formalin-fixed, paraffin-embedded human breast ductal carcinoma in situ. Using CASP3 polyclonal antibody (Cat # PAB0242) at 1 : 2000. Staining is seen in the the cancerous ducts, but not in the normal lobulus.
  • Immunoprecipitation
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 836
  • Gene Name:
  • CASP3
  • Gene Alias:
  • CPP32,CPP32B,SCA-1
  • Gene Description:
  • caspase 3, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000165054,PARP cleavage protease,SREBP cleavage activity 1,Yama,apopain,caspase 3,caspase 3, apoptosis-related cysteine protease,cysteine protease CPP32,procaspase3
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