Formalin-fixed, paraffin-embedded tissue section of human Non-Hodgkin's lymphoma (NHL) (A) and human kidney (B) stained for BIK expression. Using BIK polyclonal antibody (Cat # PAB0239) at 1 : 2000. A high level of BIK signal was seen in the distal collecting tubules, the glomeruli are primarily negative. Hematoxylin-eosin counterstain.
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. [provided by RefSeq