TMEM123 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of TMEM123. Using TMEM123 polyclonal antibody (Cat # PAB0204) at 2 ug/mL dilution against 20 ug/lane of HL-60 cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TMEM123.
Immunogen
A synthetic peptide corresponding to amino acids 173-188 of human TMEM123.
Sequence
SRRGIRYRTIDEHDAI
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% gelatin, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TMEM123. Using TMEM123 polyclonal antibody (Cat # PAB0204) at 2 ug/mL dilution against 20 ug/lane of HL-60 cell lysate. -
Gene Info — TMEM123
Entrez GeneID
114908Gene Name
TMEM123
Gene Alias
KCT3, PORIMIN, PORMIN
Gene Description
transmembrane protein 123
Omim ID
606356Gene Ontology
HyperlinkGene Summary
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq
Other Designations
keratinocytes associated transmembrane protein 3|pro oncosis receptor inducing membrane injury|pro-oncosis receptor inducing membrane injury|serine/threonine-rich receptor
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Publication Reference
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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.
Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW.
Cell 2006 Jun; 125(7):1253.
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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.
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