XAF1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XAF1.
Immunogen
A mixture of synthetic peptides corresponding to amino acids 201-218 and 301-317 of human XAF1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of XAF1 in human liver lysates using XAF1 polyclonal antibody (Cat # PAB0190) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — XAF1
Entrez GeneID
54739Gene Name
XAF1
Gene Alias
BIRC4BP, HSXIAPAF1, XIAPAF1
Gene Description
XIAP associated factor 1
Omim ID
606717Gene Ontology
HyperlinkGene Summary
X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM
Other Designations
BIRC4 binding protein
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Interactome
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Publication Reference
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XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway.
Straszewski-Chavez SL, Visintin IP, Karassina N, Los G, Liston P, Halaban R, Fadiel A, Mor G.
The Journal of Biological Chemistry 2007 Feb; 282(17):13059.
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Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.
Xia Y, Novak R, Lewis J, Duckett CS, Phillips AC.
Molecular and Cellular Biochemistry 2006 Jan; 286(1-2):67.
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X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia.
Wang X, Zhu C, Wang X, Hagberg H, Korhonen L, Sandberg M, Lindholm D, Blomgren K.
Neurobiology of Disease 2004 Jun; 16(1):179.
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XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway.
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