HDAC4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HDAC4.
Immunogen
A synthetic peptide corresponding to amino acids 194-209 of human HDAC4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
ChIP
Western Blot (Cell lysate)
Western blot analysis of HDAC-4 in Jurkat cell lysate with HDAC4 polyclonal antibody (Cat # PAB0181) .Immunoprecipitation
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Gene Info — HDAC4
Entrez GeneID
9759Gene Name
HDAC4
Gene Alias
HA6116, HD4, HDAC-A, HDACA, KIAA0288
Gene Description
histone deacetylase 4
Omim ID
605314Gene Ontology
HyperlinkGene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq
Other Designations
histone deacetylase A
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Interactome
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Disease
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Publication Reference
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HDAC4 promotes growth of colon cancer cells via repression of p21.
Wilson AJ, Byun DS, Nasser S, Murray LB, Ayyanar K, Arango D, Figueroa M, Melnick A, Kao GD, Augenlicht LH, Mariadason JM.
Molecular Biology of the Cell 2008 Jul; 19(10):4062.
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Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.
Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R.
Molecular and Cellular Biology 2005 May; 25(9):3737.
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Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters.
Caretti G, Salsi V, Vecchi C, Imbriano C, Mantovani R.
The Journal of Biological Chemistry 2003 May; 278(33):30435.
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HDAC4 promotes growth of colon cancer cells via repression of p21.
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