MBD4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MBD4.
Immunogen
A mixture of synthetic peptides corresponding to amino acids 68-282 and 337-352 of human MBD4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MBD4 in HL-60 cell lysate with MBD4 polyclonal antibody (Cat # PAB0164). A protein band of approximate molecular weight of 64 KDa was detected. -
Gene Info — MBD4
Entrez GeneID
8930Gene Name
MBD4
Gene Alias
MED1
Gene Description
methyl-CpG binding domain protein 4
Omim ID
603574Gene Ontology
HyperlinkGene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq
Other Designations
3,N(4)-ethenocytosine glycosylase|G/5-fluorouracil mismatch glycosylase with biphasic kinetics|G/T mismatch glycosylase|G/U mismatch glycosylase|putative methyl-CpG binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples.
Thatcher KN, Peddada S, Yasui DH, Lasalle JM.
Human Molecular Genetics 2005 Feb; 14(6):785.
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The localization of a methyl binding domain protein (MBD4) in murine and bovine oocytes and pre-implantation embryos.
N. Ruddock A , B , J. Xue A , B , L. Sanchez-Partida A , B , M. Cooney A , B , N. Korfiatis A , B and M. Holland A , C .
Reproduction, Feritilty and Development 2005 Jan; 17(2):210.
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Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples.
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