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Last updated: 2017/12/17
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PSENEN polyclonal antibody

  • Catalog # : PAB0141
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide conjugated to KLH.
  • Immunogen:
  • A synthetic peptide (conjugated to KLH) corresponding to N-terminus 11 amino acids of human PSENEN.
  • Host:
  • Rabbit
  • Reactivity:
  • Hamster, Human, Mouse
  • Form:
  • Lyophilized
  • Recommend Usage:
  • Western Blot (5-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from purified antibody
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with sterile water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis in rat brain homogenate (15 ug). Overnight incubation PVDF membrane with PSENEN polyclonal antibody (Cat # PAB0141) (15 ug/mL) in PBS containing 1% PBS. Horesradish peroxidase-conjugated anti-rabbit (0.5 ug/mL ; GE-Biosciences) was used for detection.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
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  • Gene Information
  • Gene Name:
  • Gene Alias:
  • MDS033,MSTP064,PEN-2,PEN2
  • Gene Description:
  • presenilin enhancer 2 homolog (C. elegans)
  • Gene Summary:
  • Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq
  • Other Designations:
  • hematopoietic stem/progenitor cells protein MDS033,presenilin enhancer 2
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