PTGES polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant purified 6-His mPGES-1.
Immunogen
Recombinant protein corresponding to human purified 6-His mPGES-1.
Host
Rabbit
Reactivity
Human, Mouse, Rat, Sheep
Form
Lyophilized
Recommend Usage
Western Blot (1:10000)
Immunohistochemistry (Frozen sections) (1:6000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from serum
Storage Instruction
Store at -20°C on dry atmosphere.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — PTGES
Entrez GeneID
9536Gene Name
PTGES
Gene Alias
MGC10317, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1
Gene Description
prostaglandin E synthase
Omim ID
605172Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq
Other Designations
MGST1-like 1|OTTHUMP00000022345|glutathione S-transferase 1-like 1|microsomal glutathione S-transferase 1-like 1|microsomal prostaglandin E synthase-1|p53-induced apoptosis protein 12|p53-induced gene 12|tumor protein p53 inducible protein 12
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress.
Huang H, Aladelokun O, Ideta T, Giardina C, Ellis LM, Rosenberg DW.
Scientific Reports 2019 Mar; 9(1):4954.
Application:WB-Ce, Human, HT-29 cells.
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Selective PGE2 suppression impairs colon carcinogenesis and modifies local mucosal immunity.
Nakanishi M, Menoret A, Tanaka T, Miyamoto S, Montrose DC, Vella A, Rosenberg DW.
Cancer Prev Res (Phila) 2011 May; 4:1198.
Application:IF, IHC-P, Mouse, Colon.
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Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress.
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