FGF2 (Human) Recombinant Protein
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Specification
Product Description
Human FGF2 recombinant protein expressed in?Baculovirus cells.
Host
Viruses
Theoretical MW (kDa)
17.3
Form
Liquid
Preparation Method
Baculovirus expression system
Purification
chromatography
Purity
> 98% as determined by (a) RP-HPLC.(b) SDS-PAGE.
Activity
ED50 < 0.5 ng/mL, measured by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake), corresponding to a Specific Activity of 2MU/mg.
Storage Buffer
In 20mM Tris buffer, pH 7.9 (20% glycerol, 100mM KCl, 1mM DTT).
Storage Instruction
Stored at 4°C for 2-4 weeks, should be stored at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — FGF2
Entrez GeneID
2247Protein Accession#
P09038Gene Name
FGF2
Gene Alias
BFGF, FGFB, HBGF-2
Gene Description
fibroblast growth factor 2 (basic)
Omim ID
134920Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq
Other Designations
basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin
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