ENG (Human) Recombinant Protein
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Specification
Product Description
Human ENG (P17813, 26 a.a. - 176 a.a.) partial-length recombinant protein expressed in Escherichia coli.
Host
Escherichia coli
Theoretical MW (kDa)
43
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 90% by HPLC and SDS PAGE
Storage Buffer
Endoglin solution?in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
SDS-PAGE
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Gene Info — ENG
Entrez GeneID
2022Protein Accession#
P17813Gene Name
ENG
Gene Alias
CD105, END, FLJ41744, HHT1, ORW, ORW1
Gene Description
endoglin
Gene Ontology
HyperlinkGene Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD105 antigen|OTTHUMP00000022221|Osler-Rendu-Weber syndrome 1
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Interactome
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Disease
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