ACVR2A (Human) Recombinant Protein
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Specification
Product Description
HumanACVR2A (P27037) recombinant protein with His-tag at C-terminal expressed in Baculovirus.
Amount
> 95% by SDS-PAGE
Sequence
AILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPLEHHHHHH.
Host
Viruses
Theoretical MW (kDa)
14.4
Form
Liquid
Preparation Method
Baculovirus expression system
Storage Buffer
Phosphate Buffered Saline (pH 7.4) and 10% glycerol
Storage Instruction
Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — ACVR2A
Entrez GeneID
92Protein Accession#
P27037Gene Name
ACVR2A
Gene Alias
ACTRII, ACVR2
Gene Description
activin A receptor, type IIA
Omim ID
102581Gene Ontology
HyperlinkGene Summary
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq
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