INHBA (Human) Recombinant Protein
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Specification
Product Description
Human INHBA (P08476, 311 a.a. - 426 a.a.) partial-length recombinant protein with His-tag at N-terminal expressed in Escherichia coli. expression system.
Amount
> 90% by SDS-PAGE
Sequence
MGSSHHHHHHSSGLVPRGSHMGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS.
Host
Escherichia coli
Theoretical MW (kDa)
15.2
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Storage Buffer
Lyophilized from 20mM Tris pH 8.0 and 10% glycerol
Storage Instruction
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles. -
Applications
SDS-PAGE
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Gene Info — INHBA
Entrez GeneID
3624Protein Accession#
P08476Gene Name
INHBA
Gene Alias
EDF, FRP
Gene Description
inhibin, beta A
Omim ID
147290Gene Ontology
HyperlinkGene Summary
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq
Other Designations
FSH-releasing protein|Inhibin, beta-1|erythroid differentiation factor|follicle-stimulating hormone-releasing protein|inhibin beta A|inhibin, beta A (activin A, activin AB alpha polypeptide)
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