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Functional Study

SDS-PAGE

Entrez GeneID

Protein Accession#

Gene Name

INHBA

Gene Alias

EDF, FRP

Gene Description

inhibin, beta A

Omim ID

Gene Ontology

Gene Summary

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq

Other Designations

FSH-releasing protein|Inhibin, beta-1|erythroid differentiation factor|follicle-stimulating hormone-releasing protein|inhibin beta A|inhibin, beta A (activin A, activin AB alpha polypeptide)