IL1R2 (Human) Recombinant Protein
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Specification
Product Description
Human IL1R2 (P27930, 14 a.a. - 343 a.a.) partial recombinant protein with His tag at C-terminus expressed in Sf9 cells.
Sequence
FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLL_x005F_x005F_x005F_x000D__x005F_x000D__x000D_ VHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKELEHHHHHH
Host
insect
Theoretical MW (kDa)
38.8
Form
Liquid
Preparation Method
Sf9 cell expression system
Purity
> 90% by SDS-PAGE
Activity
The ED50 is < 400 ng/mL with IL-1beta, measured by the ability to inhibit proliferation using D10.G4.1 mouse helper T cells.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS pH 7.4 (10% glycerol)
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IL1R2
Entrez GeneID
7850Protein Accession#
P27930Gene Name
IL1R2
Gene Alias
CD121b, IL1RB, MGC47725
Gene Description
interleukin 1 receptor, type II
Omim ID
147811Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq
Other Designations
antigen CDw121b|type II interleukin-1 receptor, beta
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Interactome
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