IGFBP4 (Human) Recombinant Protein
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Specification
Product Description
Human IGFBP4 (P22692, 22 a.a. - 258 a.a.) partial recombinant protein with His tag at C-terminus expressed in HEK293 cells.
Sequence
DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE+HisTag
Host
Mammals
Theoretical MW (kDa)
27
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% by SDS-PAGE
Activity
The ED50 is 0.01 - 0.09 ug/mL as measured by the ability to inhibit the biological activity of IGFII (20 ng/mL) on MCF7 human breast adenocarcinoma cells.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IGFBP4
Entrez GeneID
3487Protein Accession#
P22692Gene Name
IGFBP4
Gene Alias
BP-4, HT29-IGFBP, IBP4, IGFBP-4
Gene Description
insulin-like growth factor binding protein 4
Omim ID
146733Gene Ontology
HyperlinkGene Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq
Other Designations
IGF-binding protein 4|insulin-like growth factor-binding protein 4
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