INFG (Human) Recombinant Protein
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Specification
Product Description
Human INFG recombinant protein expressed in Escherichia coli.
Sequence
MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFQGRRASQ
Host
Escherichia coli
Theoretical MW (kDa)
17
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Chromatography
Purity
> 98% as determined by (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Activity
The specific activity is < 0.05 ng/mL determined by a viral resistance assay, corresponding to a specific activity of 2.0 x 10 7 IU/mg.
Storage Buffer
Lyophilized from a solution containing 1X PBS, pH 4.6. Reconstitute the lyophilized powder in ddH2O to 100 ug/mL in phosphate buffer pH >7.0 containing 0.15M NaCl.
Storage Instruction
Lyophilized protein at room temperature for 3 weeks, should be stored at -20°C. Protein aliquots at 4°C for 2-7 days and should be stored at-20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — IFNG
Entrez GeneID
3458Gene Name
IFNG
Gene Alias
IFG, IFI
Gene Description
interferon, gamma
Gene Ontology
HyperlinkGene Summary
Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly, but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007 [PubMed 17981204]).[supplied by OMIM
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