FGF2 (Human) Recombinant Protein
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Specification
Product Description
Human FGF2 (P09038) recombinant protein expressed in Escherichia coli.
Sequence
AAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Host
Escherichia coli
Theoretical MW (kDa)
17.2
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 98% by SDS-PAGE
Activity
The ED50, calculated by the dose-dependant proliferation of murine balb/c 3T3 cells is < 0.1ng/ml, corresponding to a specific activity of graeter than 1.0x107 Units/mg.
Storage Buffer
Lyophilized from 20mM Tris-HCl, pH7.4 and 1M NaCl
Storage Instruction
Lyophilized although stable at room temperature for 3 weeks, should be stored desiccated below -20°C. Upon reconstitution should be stored at 4°C between 2-7 days and for future use below -20°C.
Aliquot to avoid repeated freezing and thawing._x005F_x005F_x005F_x000D__x005F_x000D_ For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). -
Applications
Functional Study
SDS-PAGE
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Gene Info — FGF2
Entrez GeneID
2247Protein Accession#
P09038Gene Name
FGF2
Gene Alias
BFGF, FGFB, HBGF-2
Gene Description
fibroblast growth factor 2 (basic)
Omim ID
134920Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq
Other Designations
basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin
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