IL23A (Human) Recombinant Protein
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Specification
Product Description
Human IL23A recombinant protein with polyhistidine tag at the N-terminus expressed in Escherichia coli.
Sequence
RAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP with polyhistidine tag at the N-terminus.
Host
Escherichia coli
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ni-NTA chromatography
Purity
> 95% as determined by SDS-PAGE.
Endotoxin Level
< 0.1 EU per 1 ug of the protein by the LAL method.
Activity
Measured by the ability to induce IL-17 secretion in mouse splenocytes. The ED50 for this effect is < 0.5 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue.
SDS-PAGE analysis of IL23A (Human) Recombinant Protein.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from a solution containing 1X PBS, pH 8.0. Reconstitute the lyophilized powder in ddH2O to 100 ug/mL.
Storage Instruction
Lyophilized protein should be stored at -20°C. Protein aliquots should be stored at-20°C to -80°C. This product is stable for one year.
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IL23A
Entrez GeneID
51561Gene Name
IL23A
Gene Alias
IL-23, IL-23A, IL23P19, MGC79388, P19, SGRF
Gene Description
interleukin 23, alpha subunit p19
Omim ID
605580Gene Ontology
HyperlinkGene Summary
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq
Other Designations
JKA3 induced upon T-cell activation|interleukin 23 p19 subunit
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