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Functional Study

SDS-PAGE

Entrez GeneID

Protein Accession#

Gene Name

TNFRSF25

Gene Alias

APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR

Gene Description

tumor necrosis factor receptor superfamily, member 25

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq

Other Designations

OTTHUMP00000000922|OTTHUMP00000000925|apoptosis inducing receptor|apoptosis-mediating receptor|death domain receptor 3 soluble form|death receptor beta|lymphocyte associated receptor of death|translocating chain-association membrane protein|tumor necrosis