RNASE1 (Human) Recombinant Protein
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Specification
Product Description
Human RNASE1 (P07998, 29 a.a. - 156 a.a.) partial recombinant protein with His tag expressed in HEK293 cells.
Sequence
KESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
Host
Human
Theoretical MW (kDa)
15.3
Form
Liquid
Preparation Method
Mammalian cell (HEK 293) expression system
Purity
> 90% as analyzed by SDS-PAGE.
Endotoxin Level
< 1 EU/ug of protein by the LAL method.
Activity
Specific activity is > 3 x 106 unit/mg, and is defined as the amount of enzyme that cleaves 1.0 pmole of RNase probe per minute at 25°C.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue.
SDS-PAGE analysis of RNASE1 (Human) Recombinant Protein.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 ( 10% glycerol)
Storage Instruction
Store at 4°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — RNASE1
Entrez GeneID
6035Protein Accession#
P07998Gene Name
RNASE1
Gene Alias
MGC12408, RIB1, RNS1
Gene Description
ribonuclease, RNase A family, 1 (pancreatic)
Omim ID
180440Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq
Other Designations
RNase upI-1|pancreatic ribonuclease
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Interactome
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Disease
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