CD244 (Human) Recombinant Protein
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Result of bioactivity analysis
Result of bioactivity analysis
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Specification
Product Description
Human CD244 (22 a.a. - 221 a.a.) partial recombinant protein with hFc tag at C-terminus expressed in HEK293 cells.
Host
Mammals
Theoretical MW (kDa)
73.5999999999998
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1 EU per 1 ug of protein (determined by gel clotting method)
Activity
Immobilized SLAMF2 (Mammalian, C-mFc) at 1.0 ug/mL, 2.0 ug/mL (100 uL/well) can bind 2B4/CD244, hFc, Human with EC50=48.56 ng/mL, EC50=75.13 ng/mL when detected by Mouse Anti Human IgG Fc-HRP.
Storage Buffer
Lyophilized from sterile distilled Water up to 100 ug/mL
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — CD244
Entrez GeneID
51744Gene Name
CD244
Gene Alias
2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Gene Description
CD244 molecule, natural killer cell receptor 2B4
Omim ID
605554Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells express both activating and inhibitory cell surface receptors. Inhibitory signaling receptors all possess cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, or ITIMs, whereas the activating receptors lack ITIMs and associate with DAP12 (TYROBP; MIM 604142), which contains an immunoreceptor tyrosine-based activation motif, or ITAM. Killer cell immunoglobulin (Ig)-like receptors, or KIRs (see KIR2DL1; MIM 604936), and other NK cell receptors interact with major histocompatibility complex (MHC) molecules (see MIM 142800). Members of the CD2 (MIM 186990) family adhere to each other instead. The cell surface glycoprotein 2B4 is related to CD2 and is implicated in the regulation of NK- and T-cell function (Boles et al., 1999 [PubMed 10458320]).[supplied by OMIM
Other Designations
CD244 natural killer cell receptor 2B4|NK cell activation inducing ligand NAIL|OTTHUMP00000027884|natural killer cell receptor 2B4
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Interactome
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Disease
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