CTLA4 (Human) Recombinant Protein
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Human CTLA4 (P16410, 37 a.a. - 162 a.a.) partial recombinant protein with hFc tag at C-terminus expressed in CHO cell.
Sequence
AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDF
Host
Mammals
Theoretical MW (kDa)
45-48
Form
Lyophilized
Preparation Method
Mammalian cell (CHO) expression system
Purity
> 98% by SDS-PAGE
Endotoxin Level
< 0.2 EU per 1 ug of protein (determined by gel clotting method)
Activity
Measured by the ability to inhibit IL-2 secretion by co-culturing stimulated Jurkat human acute T cell leukemia cells and CD80 expression CHO stable cell line. Immobilized B7-2 (CD86), His, Human at 2.0 ug/mL (100 uL/well) can bind CTLA-4, hFc, Human.
Storage Buffer
Lyophilized from sterile distilled Water up to 100 ug/mL
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
-
Applications
Functional Study
SDS-PAGE
-
Gene Info — CTLA4
Entrez GeneID
1493Protein Accession#
P16410Gene Name
CTLA4
Gene Alias
CD152, CELIAC3, CTLA-4, GSE, IDDM12
Gene Description
cytotoxic T-lymphocyte-associated protein 4
Gene Ontology
HyperlinkGene Summary
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq
Other Designations
OTTHUMP00000163781|cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com