PDCD1 (Human) Recombinant Protein
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Specification
Product Description
Human PDCD1 (Q15116, 25 a.a. - 167 a.a.) partial recombinant protein with hFc tag at C-terminus expressed in CHO cell.
Sequence
LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQ
Host
Mammals
Theoretical MW (kDa)
60-65
Form
Lyophilized
Preparation Method
Mammalian cell (CHO) expression system
Purity
> 98% by SDS-PAGE
Endotoxin Level
< 0.2 EU per 1 ug of protein (determined by gel clotting method)
Activity
Immobilized PD-L1, hFc, Human at 1.0 ug/mL (100 uL/well) can bind biotinylated PD-1, hFc, Human. Immobilized PD-L1, His, Human at 2.0 ug/mL (100 uL/well) can bind PD-1, hFc, Human.
Storage Buffer
Lyophilized from sterile distilled Water up to 100 ug/mL
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — PDCD1
Entrez GeneID
5133Protein Accession#
Q15116Gene Name
PDCD1
Gene Alias
CD279, PD1, SLEB2, hPD-1, hPD-l
Gene Description
programmed cell death 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq
Other Designations
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Interactome
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