CTSB (Human) Recombinant Protein
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Specification
Product Description
Human CTSB (P07858, 18 a.a. - 339 a.a.) partial recombinant protein with His tag at C-teminus expressed in CHO cell.
Sequence
RSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Host
Mammals
Theoretical MW (kDa)
43
Form
Liquid
Preparation Method
Mammalian cell (CHO) expression system
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 0.2 EU per 1 ug of protein (determined by gel clotting method)
Storage Buffer
In 25 mM Tris-HCl buffer, 150 mM NaCl, pH 8.0 (20% glycerol)
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — CTSB
Entrez GeneID
1508Protein Accession#
P07858Gene Name
CTSB
Gene Alias
APPS, CPSB
Gene Description
cathepsin B
Omim ID
116810Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
APP secretase|OTTHUMP00000116009|amyloid precursor protein secretase|cathepsin B1|cysteine protease|preprocathepsin B
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Interactome
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Disease
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