TNFSF18 (Human) Recombinant Protein
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Specification
Product Description
Human TNFSF18 (Q9UNG2, 74 a.a. - 198 a.a ) partial recombinant protein expressed in Escherichia coli.
Sequence
MSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
Host
Escherichia coli
Theoretical MW (kDa)
14.3
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 95% as analyzed by SDS-PAGE.
Endotoxin Level
< 0.2 EU/ug of protein by gel clotting method
Activity
ED50 < 5.0 ng/mL, measured by the amount of Interleukin-8 produced by PMBC, corresponding to a specific activity of > 2.0 × 105 units/mg.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 50 mM Tris, pH 8.0. Reconstitute the lyophilized powder in ddH2O up to 100 ug/mL.
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — TNFSF18
Entrez GeneID
8995Protein Accession#
Q9UNG2Gene Name
TNFSF18
Gene Alias
AITRL, GITRL, MGC138237, TL6, hGITRL
Gene Description
tumor necrosis factor (ligand) superfamily, member 18
Omim ID
603898Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq
Other Designations
AITR ligand|GITR ligand|glucocorticoid-induced TNFR-related protein ligand
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