COL18A1 (Human) Recombinant Protein
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Specification
Product Description
Human COL18A1 (P39060, 1571 a.a. - 1754 a.a.) partial recombinant protein expressed in Pichia pastoris.
Sequence
AHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHAYIVLCIENSFMTASK
Host
Yeast
Theoretical MW (kDa)
20.2
Form
Lyophilized
Preparation Method
Pichia pastoris expression system
Purity
> 97% by SDS-PAGE
Endotoxin Level
< 1 EU per 1 ug of protein (determined by gel clotting method)
Activity
Determined by Endothelial Cell Tube Formation. The cells treated with 10 ug/ml Endostatin showed significant anti-angiogenesis effect.
Storage Buffer
Lyophilized from sterile distilled Water up to 100 ug/ml
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — COL18A1
Entrez GeneID
80781Protein Accession#
P39060Gene Name
COL18A1
Gene Alias
FLJ27325, FLJ34914, KNO, KNO1, MGC74745
Gene Description
collagen, type XVIII, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000115472|OTTHUMP00000115473|alpha 1 type XVIII collagen|antiangiogenic agent|endostatin|multi-functional protein MFP
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Disease
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