ACVR1 (Human) Recombinant Protein
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Functional Study
The ED50 for this effect is <0.85 ng/mL, measured by the induction of hemoglobin expression in K562 cells.
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Specification
Product Description
Human ACVR1 recombinant protein with polyhistidine tag at the C-terminus expressed in Escherichia coli.
Sequence
MGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Host
Escherichia coli
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ni-NTA chromatography
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 0.1 EU per 1 ug of the protein by the LAL method.
Activity
Measured by the induction of hemoglobin expression in K562 cells. The ED 50 for this effect is < 0.85 ng/mL. The specific activity of recombinant human Activin A is approximately > 1.4 x 103 IU/mg.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.1% sarkosyl, PBS, pH 8.0.
Storage Instruction
Store at -20°C, lyophilized protein is stable for 1 year.
After reconstitution with deionized water, store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
The ED50 for this effect is <0.85 ng/mL, measured by the induction of hemoglobin expression in K562 cells.SDS-PAGE
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Gene Info — ACVR1
Entrez GeneID
90Gene Name
ACVR1
Gene Alias
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Gene Description
activin A receptor, type I
Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq
Other Designations
TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 2|activin A type I receptor|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
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