IL6 (Human) Recombinant Protein
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More Files
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Functional Study
The ED50 for this effect is <0.5 ng/mL, measured by the induction of proliferation in TF-1 cells.
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Specification
Product Description
Human IL6 recombinant protein with His tag expressed in Escherichia coli.
Sequence
MVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Host
Escherichia coli
Theoretical MW (kDa)
22-28
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ni-NTA chromatography
Purity
> 98% by SDS-PAGE
Endotoxin Level
< 0.1 EU/ug
Activity
Measured by the induction of proliferation in TF-1 cells The ED50 for this effect is < 0.5 ng/mL. The specific activity is approximately > 5 x 108 IU/mg.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 8.0.
Storage Instruction
Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C. Avoid repeated freezing and thawing.
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Applications
Functional Study
The ED50 for this effect is <0.5 ng/mL, measured by the induction of proliferation in TF-1 cells.SDS-PAGE
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Gene Info — IL6
Entrez GeneID
3569Gene Name
IL6
Gene Alias
BSF2, HGF, HSF, IFNB2, IL-6
Gene Description
interleukin 6 (interferon, beta 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq
Other Designations
interleukin 6
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Interactome
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Pathway
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Disease
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