FOLR2 (Human) Recombinant Protein
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Result of bioactivity analysis
Result of bioactivity analysis
Folic Acid-BSA is coated at 10 ug/mL (100 uL/well) can bind FOLR2 (Human) Recombinant Protein (Cat # P6986). The ED50 range ≤ 5 ug/mL.
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Specification
Product Description
Human FOLR2 (NP_000794.3, 22 a.a.- 230 a.a.) partial recombinant protein with C-terminal His tag expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
25.1
Form
Liquid
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 90% by SDS-PAGE
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method).
Activity
Measured by the binding ability in a functional ELISA with Folic Acid-BSA. The ED50 range ≤ 5 ug/mL.
Quality Control Testing
3 ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Recommend Usage
Bioactivity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — FOLR2
Entrez GeneID
2350Protein Accession#
NP_000794.3Gene Name
FOLR2
Gene Alias
BETA-HFR, FBP/PL-1, FR-BETA, FR-P3
Gene Description
folate receptor 2 (fetal)
Omim ID
136425Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq
Other Designations
folate receptor 2|folate receptor, beta|folate-binding protein, fetal/placental
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