IL1A (Human) Recombinant Protein
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Result of bioactivity analysis
Result of bioactivity analysis
IL1A (Human) Recombinant Protein stimulates cell proliferation of the D10.G4.1 mouse helper T cell. The ED50 range is less or equal to 0.04 ng/mL.
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Specification
Product Description
Human IL1A (NP_000566, 113 a.a. - 271 a.a.) partial recombinant protein with His tag expressed in Escherichia coli.
Host
Human
Theoretical MW (kDa)
22.4
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 90% by SDS-PAGE
Endotoxin Level
> 1 EU per 1ug of protein (determined by LAL method)
Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 for this effect is less or equal to 0.04 ng/ml.
Quality Control Testing
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In 20mM Tris-HCl, pH 7.5 (10% glycerol)
Storage Instruction
Stored at 2°C to 8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — IL1A
Entrez GeneID
3552Protein Accession#
NP_000566Gene Name
IL1A
Gene Alias
IL-1A, IL1, IL1-ALPHA, IL1F1
Gene Description
interleukin 1, alpha
Omim ID
147760Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq
Other Designations
IL1A (IL1F1)|hematopoietin-1|preinterleukin 1 alpha|pro-interleukin-1-alpha
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Interactome
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Pathway
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Disease
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