CNTF (Human) Recombinant Protein
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Specification
Product Description
Human CNTF (NP_000605, 1 - 200 a.a.) full length recombinant protein with His tag expressed in Escherichia coli expression system.
Host
Escherichia coli
Theoretical MW (kDa)
25
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1 EU/ug
Activity
Human CNTF in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 1 ug/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
3 ug SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, 0.2 M NaCl, 1 mM DTT, pH 8.5 (30% glycerol)
Storage Instruction
Store at 4°C for one week. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — CNTF
Entrez GeneID
1270Protein Accession#
P26441Gene Name
CNTF
Gene Alias
HCNTF
Gene Description
ciliary neurotrophic factor
Omim ID
118945Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq
Other Designations
OTTHUMP00000174731
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