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Last updated: 2022/5/22

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HNMT (Human) Recombinant Protein BioActive

  • Catalog # : P6829
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  • Specification
  • Product Description:
  • Human Histamine N-Methyltransferase/HNMT protein (AAH20677, 1 a.a.-292 a.a.) full length recombinant protein with His tag expressed in Escherichia coli.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 37.4
  • Form:
  • Liquid
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • > 90% by SDS-PAGE
  • Activity:
  • Specific activity is > 200 nmol/min/mg, and is defined as the amount of enzyme that transfer 1.0 nmole of methyl group per minute at 37°C.
  • Quality Control Testing:
  • SDS-PAGE under reducing condition and visualized by coomassie blue stain.

    QC Testing of P6829
    SDS-PAGE under reducing condition and visualized by coomassie blue stain.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris-HCl, pH 8.0 (10% glycerol)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • SDS-PAGE
  • Application Image
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3176
  • Gene Name:
  • HNMT
  • Gene Alias:
  • HMT,HNMT-S1,HNMT-S2
  • Gene Description:
  • histamine N-methyltransferase
  • Gene Summary:
  • In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq
  • Other Designations:
  • -
  • Gene Pathway
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