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Last updated: 2022/5/22

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AKR1C4 (Human) Recombinant Protein BioActive

  • Catalog # : P6808
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human AKR1C4 (NP_001809, 1 a.a. - 323 a.a.) full length recombinant protein expressed in Escherichia coli.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 37
  • Form:
  • Liquid
  • Preparation Method:
  • Escherichia coli expression system
  • Purity:
  • > 90% by SDS-PAGE
  • Endotoxin Level:
  • < 1 EU/ug
  • Activity:
  • Specific activity is > 700 pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1.0 pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25°C.
  • Quality Control Testing:
  • SDS-PAGE Stained with Coomassie Blue

    QC Testing of P6808
    15% SDS-PAGE Stained with Coomassie Blue.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM DTT, pH 8.5 (10% glycerol)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • SDS-PAGE
  • Application Image
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 1109
  • Gene Name:
  • AKR1C4
  • Gene Alias:
  • 3-alpha-HSD,C11,CDR,CHDR,DD4,HAKRA,MGC22581
  • Gene Description:
  • aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
  • Gene Summary:
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
  • Other Designations:
  • 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4,OTTHUMP00000018997,aldo-keto reductase family 1, member C4,chlordecone reductase,dihydrodiol dehydrogenase 4,dihydrodiol dehydrogenase isozyme DD4,type I 3-alpha-hydroxysteroid dehydrogenase
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