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Last updated: 2022/7/3

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SIRPA (Human) Recombinant Protein BioActive

  • Catalog # : P6787
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human SIRPA (NP_542970.1, 31 a.a. - 370 a.a.) partial recombinant protein with Fc, 6x His tag at C-terminal expressed in HEK293 cells.
  • Host:
  • Human
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (HEK293) expression system
  • Purification:
  • Ni-sepharose purification
  • Purity:
  • > 95% by SDS-PAGE
  • Endotoxin Level:
  • < 0.1 EU/ug of the protein by LAL method.
  • Activity:
  • Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CD47 at 1 ug/mL (100 uL/well) can bind SIRPA (Human) Recombinant Protein (Cat # P6787) with a linear range of 1-6 ng/mL.
  • Quality Control Testing:
  • SDS-PAGE Stained with Coomassie Blue

    QC Testing of P6787
    SIRPA (Human) Recombinant Protein (Cat # P6787) was determined by SDS-PAGE with Coomassie Blue, showing a band at 80-100 kDa.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS, pH 7.4.
  • Storage Instruction:
  • Store the lyophilized protein at -20°C to -80°C for long term.
    After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Immunogen
  • SDS-PAGE
  • Application Image
  • Immunogen
  • SDS-PAGE
  • Gene Information
  • Gene Name:
  • SIRPA
  • Gene Alias:
  • BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS-1,SHPS1,SIRP,SIRP-ALPHA-1,SIRPalpha,SIRPalpha2
  • Gene Description:
  • signal-regulatory protein alpha
  • Gene Summary:
  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000030001,SHP substrate-1,brain-immunoglobulin-like molecule with tyrosine-based activation motifs,macrophage fusion receptor,myd-1 antigen,protein tyrosine phosphatase, non-receptor type substrate 1,signal regulatory protein, alpha type 1,signal
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