IL21R (Human) Recombinant Protein
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Specification
Product Description
Human IL21R (NP_068570.1, 20 a.a. - 236 a.a.) partial recombinant protein with 6x His tag at C-terminal expressed in HEK293 cells.
Host
Human
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 90% by SDS-PAGE
Endotoxin Level
< 0.1 EU/ug of the protein by LAL method.
Activity
Measured by the binding ability in a functional ELISA. Immobilized IL21R (Human) Recombinant Protein (Cat # P6779) at 2 ug/mL (100 uL/well) can bind Recombinant Human IL-21 with a linear range of 0.128-5.63 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
IL21R (Human) Recombinant Protein (Cat # P6779) was determined by SDS-PAGE with Coomassie Blue, showing a band at 40-50 kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — IL21R
Entrez GeneID
50615Protein Accession#
NP_068570.1Gene Name
IL21R
Gene Alias
MGC10967, NILR
Gene Description
interleukin 21 receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
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