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Last updated: 2022/5/22

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IL21R (Human) Recombinant Protein BioActive

  • Catalog # : P6779
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  • Specification
  • Product Description:
  • Human IL21R (NP_068570.1, 20 a.a. - 236 a.a.) partial recombinant protein with 6x His tag at C-terminal expressed in HEK293 cells.
  • Host:
  • Human
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (HEK293) expression system
  • Purification:
  • Ni-sepharose purification
  • Purity:
  • > 90% by SDS-PAGE
  • Endotoxin Level:
  • < 0.1 EU/ug of the protein by LAL method.
  • Activity:
  • Measured by its binding ability in a functional ELISA. Immobilized IL21R (Human) Recombinant Protein (Cat # P6779) at 2 ug/mL (100 uL/well) can bind Recombinant Human IL-21 with a linear range of 0.128-5.63 ng/mL.
  • Quality Control Testing:
  • SDS-PAGE Stained with Coomassie Blue

    QC Testing of P6779
    IL21R (Human) Recombinant Protein (Cat # P6779) was determined by SDS-PAGE with Coomassie Blue, showing a band at 40-50 kDa.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS, pH 7.4.
  • Storage Instruction:
  • Store the lyophilized protein at -20°C to -80°C for long term.
    After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Immunogen
  • SDS-PAGE
  • Application Image
  • Immunogen
  • SDS-PAGE
  • Gene Information
  • Gene Name:
  • IL21R
  • Gene Alias:
  • MGC10967,NILR
  • Gene Description:
  • interleukin 21 receptor
  • Gene Summary:
  • The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
  • Other Designations:
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