LEPR (Human) Recombinant Protein
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Specification
Product Description
Human LEPR (NP_002294.2, 20 a.a. - 839 a.a.) partial recombinant protein with Fc and His tag at C-terminus expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
170-190
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1.0 EU/ug
Activity
Measured by the binding ability in a functional ELISA. Immobilized Recombinant Human Leptin protein at 2 ug/mL (100 uL/well) can bind Recombinant Human Leptin R/CD295 protein, the EC50 of Leptin R/CD295 is 261.45 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
LEPR (Human) Recombinant Protein (Cat #P6771) was determined by SDS-PAGE with Coomassie Blue, showing a band at 170-190 kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — LEPR
Entrez GeneID
3953Protein Accession#
P48357Gene Name
LEPR
Gene Alias
CD295, OBR
Gene Description
leptin receptor
Omim ID
601007Gene Ontology
HyperlinkGene Summary
Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM
Other Designations
OB receptor|OTTHUMP00000010693|OTTHUMP00000010694
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